Klinisch relevante subgroepen knieartrose patiënten

Given the low to moderate effects of current symptomatic treatment options for knee osteoarthritis (OA) and the known heterogeneity of knee osteoarthritis patients, there is a general call for the evaluation of clinically relevant subgroups that could benefit more from certain interventions. We aim to evaluate the presence of clinically relevant subgroups of OA patients for the core treatment options across the span of treatment options for knee OA; anti-inflammatory analgesics, corticosteroid injections and exercise therapy. In data of two high-quality randomized controlled trials (RCTs), of which members of the project group were actively involved, we will evaluate several pre-defined subgroups of knee OA patients. Additionally, after a systematic search of the literature, we will reach out to all authors of all published RCTs on pre- and post-surgery exercise therapy for knee OA. Based on the Individual Patient Data (IPD) from these published trials, we will do an IPD meta-analyses for clinically relevant knee OA patients; the highest standard of subgroup analyses.