Kosteneffecitiviteit van ondansetron bij kinderen met diarree en braken op de huisartsenpost
Titel onderzoek Nederlands
Titel onderzoek Engels
Onderzoeksvraag
Uitgangsvraag PICO
P
Vomiting children aged 6 months to 6 years with AGE attending OHS
I
Oral ondansetron added to ORT
C
ORT
O
Referrals to a paediatric emergency department
Onderzoeksinstituut
Universitair Medisch Centrum GroningenSamenvatting van het onderzoek
Objective: To evaluate cost-effectiveness of ondansetron in children with acute gastro-enteritis (AGE) and vomiting at a general practitioner cooperative out-of-hours service (OHS).
Research question & Hypothesis: What is the cost-effectiveness of ondansetron and oral rehydration therapy (ORT) compared to ORT alone? We hypothesize that with an effective one-intake-treatment that stops vomiting and consequently facilitates ORT, referral rate will be reduced and consequently will reduce costs.
Methods: This is a pragmatic randomized controlled trial. We will include vomiting children aged 6 months to 6 years with AGE attending an OHS.
Intervention: We will compare oral ondansetron added to ORT with ORT alone (usual care).
Primary clinical outcome: the number of referrals to a paediatric emergency department.
Sample size: We have to include 1.064 children in order to observe a significant reduction in referral rate from an expected 9% to 4.5%.
Startdatum onderzoek
Type onderzoek
Aard van het onderzoek
Design van het onderzoek
Onderzoeker
Contactpersoon
Dr. Y. Lisman-van Leeuwen, projectleiderAndere betrokkenen
Prof. dr. M.Y. Berger, afdelingshoofd en huisarts
Dr. J. Post, huisarts
Dr. M.H. Blanker, universitair docent en huisarts