Screening op slokdarmkanker: is er draagvlak voor een bevolkingsonderzoek onder professionals en de algemene bevolking?
Titel onderzoek Nederlands
Titel onderzoek Engels
- Individuals of the general population
- Individuals at high risk for EAC
- Health care professionals that may become involved in the development and/or daily practice of an EAC screening program
EAC screening, defined as (systematically) offering a screening exam (i.e. innovative less-invasive screening modalities such as unsedated transnasal endoscopy, non-endoscopic cell collection devices or breath analysis) with the purpose of early detection of EAC, offered to individuals at risk for EAC (i.e. patients with GERD with or without other risk factors), with no previous endoscopies, in a primary or secondary care setting.
- Acceptability of EAC screening
- Predicted uptake of EAC screening
- Preferences for different EAC screening strategies
- Ethical, legal and social implications (ELSI) for implementation of EAC screening
Note: the PICO format is not completely applicable to our research design.
Samenvatting van het onderzoek
The ongoing increasing incidence of esophageal adenocarcinoma (EAC) during the last few decades and its dismal prognosis has stimulated interest in screening for its precursor Barrett’s esophagus (BE). Screening programs to detect BE followed by endoscopic surveillance and treatment of dysplasia and early neoplasia may reduce the incidence of EAC and thereby reduce mortality.
However, implementation of EAC screening could face considerable challenges. A key factor driving the success or failure of EAC screening is the acceptability and support among professionals and the general population.
The aims of this project are to explore determinants associated with potential implementation of EAC screening and to make an inventory on communication, medico-legal and ethical considerations related to EAC screening.
1) Create an overview of the current literature on acceptability and motivators and barriers to screening for EAC by using systematic literature review.
2) Perform a concept mapping study with national and international professionals to investigate their perceptions of EAC screening.
3) Conduct focus group discussions with Dutch individuals at-risk for EAC to investigate perceptions that determine their support for screening followed by treatment or surveillance of Barrett’s esophagus.
4) Develop and distribute a questionnaire based on the collected information and themes from sections 1 to 3 in a larger sample of the population to investigate the acceptability and predicted uptake of EAC screening.
5) Organize a patient and interdisciplinary expert meeting to discuss implications and recommendations for future screening studies and potential future implementation of (risk-based) EAC screening approaches.
Aard van het onderzoek
Design van het onderzoek